Kisner was born in Aiken, South Carolina. He played college golf at the University of Georgia and was a member of their 2005 NCAA Division I Championship team along with Chris Kirk, Richard Scott and Brendon Todd. After graduating in 2006, he turned professional.
Kisner played on the mini-tours (NGA Hooters Tour Tarheel Tour) and from 2007 to 2009, winning three times. He also played in six Nationwide Tour events in 2009. He played the Nationwide Tour full-time in 2010, winning once at the Mylan Classic. He finished the year 11th on the money list and earned his 2011 PGA Tour card.